The Global 3Rs Awards program, a collaboration between AAALAC International and the IQ Consortium, has recognized the following individuals for their significant innovative contributions toward the 3Rs of animal research to advance ethical science in academia or industry in any area of biology. The 2017 winners are: Marcel Leist, Chair for In Vitro Toxicology and Biomedicine at the University of Konstanz in Germany, and Mark E. Smith, Chief Scientific Officer at American Preclinical Services (APS) in Minneapolis, Minnesota, USA.