On October 11, NICEATM released version 3.5 of the Integrated Chemical Environment (ICE; https://ice.ntp.niehs.nih.gov/). ICE provides data and tools to help develop, assess, and interpret chemical safety tests. This release adds expanded capabilities and new data to the existing ICE resources.
ICE version 3.5 includes the following expanded capabilities:
- New result selection options in the Chemical Quest and Curve Surfer tools.
- Application of Saagar fingerprints (described in Sedykh et al. 2021: https://doi.org/10.1021/acs.chemrestox.0c00464) to Chemical Quest searches.
- Ability to display AC50 plots in Search results.
In addition, updated data have been added for acute oral toxicity, cancer, and skin sensitization, and modeling tools are using updated absorption, distribution, metabolism, and excretion data.