The National Institutes of Health (NIH) Common Fund is planning a program to catalyze the development, standardization, validation, and use of new approach methodologies (NAMs) that will more accurately model human outcomes. As part of the Complement-Animal Research In Experimentation (Complement-ARIE) strategic planning process, the Office of Strategic Coordination intends to publish a prize competition announcement to solicit entries for new methods and approaches that would complement, make more efficient, or in some cases replace traditional animal models, transforming the way biomedical researchers conduct basic, translational, and clinical sciences.

The September 21 notice, available at, provides potential solvers with available details about the Complement-ARIE Challenge. Publication of the Challenge announcement and launch of the submission portal are planned for November 7. Potential applicants are encouraged to visit and sign up for the Complement-ARIE listserv to receive updates about the Challenge. The estimated deadline for submissions is January 11, 2024.