The Occupational and Inhalation Exposures Research Program within the Division of Translational Toxicology at the National Institute of Environmental Health Sciences (NIEHS) recently released a “Request for Information (RFI) on the Use of In Vitro Lung Models in Inhalation Toxicology Research with Potential Application to Regulatory Decision-Making.” Responses to this RFI will guide the Division’s research in this area and align it with the needs of the broader research and regulatory communities. Respondents are specifically asked to provide information about:

  • Applications for which in vitro lung models have been used.
  • The most important scientific knowledge gaps underlying the assessment of the effects of inhaled substances on human health.
  • Current technical challenges and limitations related to using in vitro lung models in research.
  • Ongoing concerted efforts by individuals or groups to utilize in vitro lung models in routine hazard or risk assessment.

Respond by June 7 at More information about the RFI is available at or at