Funding available for NAMs technology development centers

The National Institutes of Health (NIH) Common Fund, along with the Office of the NIH Director, Office of Strategic Coordination has published a Notice of Funding Opportunity to support the Complement Animal Research in Experimentation (Complement-ARIE) Program. The funding opportunity will be administered by the National Center for Advancing Translational Sciences on behalf of NIH. Complement-ARIE will accelerate the development, standardization, validation, and use of human-based NAMs.

Investigators with expertise and insights into the area of NAMs are encouraged to consider applying for these funding opportunities. Funding will support technology development centers that will stimulate the development of combinatorial NAMs to support scientific areas of need, with emphasis on increased biological complexity and throughput, innovative combinatorial approaches, and data sharing according to findability, accessibility, interoperability, and reusability (FAIR) principles. Developing these NAMs will require multi-disciplinary expertise in disease research, personalized medicine, screening therapeutics for safety and efficacy, and regulatory science. The NIH Common Fund intends to commit approximately $18M per year to fund 4-5 awards. Letters of intent are due January 24, 2025. Applications will be accepted starting January 28 and will be due February 28.

Complement-ARIE program goals include:

• To better model and understand human health and disease outcomes across diverse populations.
• To develop NAMs that provide insight into specific biological processes or disease states.
• To validate mature NAMs to support regulatory use and standardization.
• To complement traditional models and make biomedical research more efficient and effective.

For eligibility and award information, and to apply, visit https://grants.nih.gov/grants/guide/rfa-files/RFA-RM-24-010.html.