[Modern drug development by molecular- and cellbiological methods] [Article in German] LINZ 2000
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Abstract
V79 cells have been genetically modified for metabolism functions of humans in drug metabolism and metabolic activation of chemicals. All V79 constructs together form the V79 Cell Battery by which GenPharmTox BioTech AG, Tutzing, Germany, is capable of checking drug metabolism early on during preclinical drug development with immediate relevance for the clinical testing of drugs. It is impossible to obtain those data from animal testing. Therefore, the intrinsic problems in extrapolating data generated from animal testing to humans has been circumvented.
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