[Influence of the preservative thiomersal on the Interleukin-1-Beta release of human peripheral blood cells] [Article in German]: LINZ 2000

Matthias Fischer; Brigitte Keller-Stanislawski; Susanne Schober-Bendixen; Rudolf Schosser; Katrin Hacke; Thomas Hartung; Thomas Montag

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Published: Feb 1, 2001

Matthias Fischer , Brigitte Keller-Stanislawski, Susanne Schober-Bendixen, Rudolf Schosser, Katrin Hacke, Thomas Hartung, Thomas Montag
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Abstract

Several vaccines have been tested in the human whole blood pyrogen test as an alternative to the rabbit pyrogen test. As reported previously by our group, the alternative testsystem is basically applicable to vaccines. The widely used conservative thiomersal is influencing the test system. Surprisingly, the induction of fever inducing cytokines by endotoxin contaminations and other pyrogens can be suppressed by thiomersal.

How to Cite

Fischer, M. (2001) “[Influence of the preservative thiomersal on the Interleukin-1-Beta release of human peripheral blood cells] [Article in German]: LINZ 2000”, ALTEX - Alternatives to animal experimentation, 18(1), pp. 47–49. Available at: https://altex.org/index.php/altex/article/view/1374 (Accessed: 19 April 2024).

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Vol. 18 No. 1 (2001)

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