[Newer knowledge concerning a protective antigen of erysipelothrix rhusiopathiae] [Article in German]

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Published: Jan 1, 1994

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Reinhard Weiss, Martin H. Groschup, Claudia Nakov
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Abstract

Investigations on extracts from carried out within the last few years yielded the identification of a species-specific proteinaceous antigen of 66-64 kDa. The protective properties of this protein presented in particular in crude NaOH and NaOH-EDTA but not in acid and heat extracts could be demonstrated in mice and pigs vaccinated with the electroeluted 66-64 kDa antigen or treated with polyclonal and monoclonal antibodies, respectively. The identification and characterisation of the 66-64 kDa protein as a protective antigen of (E.) rhusiopathiae can be regarded as a basis for a possible replacement of the official mouse protection test in vaccine testing by an in vitro assay.

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How to Cite
Weiss, R., Groschup, M. H. and Nakov, C. (1994) “[Newer knowledge concerning a protective antigen of erysipelothrix rhusiopathiae] [Article in German]”, ALTEX - Alternatives to animal experimentation, 11(Supp. 1), pp. 35–38. Available at: https://altex.org/index.php/altex/article/view/2040 (Accessed: 21 May 2025).
Issue
Vol. 11 No. Supp. 1 (1994): Paul-Ehrlich-Seminar über Tierschutzaspekte bei der Zulassung und Prüfung von immunologischen Arzneimitteln
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