A call for a Human Exposome Project

Food for Thought ...

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Boekelheide, K. and Campion, S. N. (2010). Toxicity testing in the 21st century: Using the new toxicity testing paradigm to create a taxonomy of adverse effects. Toxicol Sci 114, 20-24. doi:10.1093/toxsci/kfp307

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Bottini, A. A. and Hartung, T. (2009). Food for thought ... on the economics of animal testing. ALTEX 26, 3-16. doi:10.14573/altex.2009.1.3

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Carmichael, P. L., Baltazar, M. T., Cable, S. et al. (2022). Ready for regulatory use: NAMs and NGRA for chemical safety assurance. ALTEX 39, 359-366. doi:10.14573/altex.2204281

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Chesnut, M., Yamada, T., Adams, T. et al. (2018). Regulatory acceptance of read-across: Report from an international satellite meeting at the 56th annual meeting of the society of toxicology. ALTEX 35, 413-419. doi:10.14573/altex.1805081

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Daneshian, M., Botana, L. M., Dechraoui Bottein, M. Y. et al. (2013). A roadmap for hazard monitoring and risk assessment of marine biotoxins on the basis of chemical and biological test systems. ALTEX 30, 487-545. doi:10.14573/altex.2013.4.487

Daneshian, M., Busquet, F., Hartung, T. et al. (2015). Animal use for science in Europe. ALTEX 32, 261-274. doi:10.14573/altex.1509081

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de Vries, R. B. M., Angrish, M., Browne, P et al. (2021). Applying evidence-based methods to the development and use of adverse outcome pathways. ALTEX 38, 336-347. doi:10.14573/altex.2101211

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Eisenman, S. F. (2016). Criticizing animal experimentation, at my peril. ALTEX 33, 3-12. doi:10.14573/altex.1509282

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Gordon, S., Daneshian, M., Bouwstra, J. et al. (2015). Non-animal models of epithelial barriers (skin, intestine and lung) in research, industrial applications and regulatory toxicology. ALTEX 32, 327-378. doi:10.14573/altex.1510051

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Hardy, B., Apic, G., Carthew, P. et al. (2012). Food for thought ... a toxicology ontology roadmap. ALTEX 29, 129-137. doi:10.14573/altex.2012.2.129

Hartung, T., Balls, M., Bardouille, C. et al. (2002). Good cell culture practice. ECVAM good cell culture practice task force report 1. Altern Lab Anim 30, 407-414. doi:10.1177/026119290203000404

Hartung, T., Bremer, S., Casati, S. et al. (2004). A modular approach to the ECVAM principles on test validity. Altern Lab Anim 32, 467-472. doi:10.1177/026119290403200503

Hartung, T. (2007a). Food for thought ... on validation. ALTEX 24, 67-72. doi:10.14573/altex.2007.2.67

Hartung, T. (2007b). Food for thought ... on cell culture. ALTEX 24, 143-147. doi:10.14573/altex.2007.3.143

Hartung, T. (2008a). Food for thought ... on alternative methods for cosmetics safety testing. ALTEX 25, 147-162. doi:10.14573/altex.2008.3.147

Hartung, T. (2008b). Food for thought ... on animal tests. ALTEX 25, 3-16. doi:10.14573/altex.2008.1.3

Hartung, T. and Leist, M. (2008). Food for thought ... on the evolution of toxicology and the phasing out of animal testing. ALTEX 25, 91-102. doi:10.14573/altex.2008.2.91

Hartung, T. and Koëter, H. (2008). Food for thought ... on food safety testing. ALTEX 25, 259-264. doi:10.14573/altex.2008.4.259

Hartung, T. (2009a). A toxicology for the 21st century: Mapping the road ahead. Tox Sci 109, 18-23. doi:10.1093/toxsci/kfp059

Hartung, T. (2009b). Food for thought ... on evidence-based toxicology. ALTEX 26, 75-82. doi:10.14573/altex.2009.2.75

Hartung, T. and Hoffmann, S. (2009). Food for thought ... on in silico methods in toxicology. ALTEX 26, 155-166. doi:10.14573/altex.2009.3.155

Hartung, T., Blaauboer, B. and Leist, M. (2009). Food for thought ... on education in alternative methods in toxicology. ALTEX 26, 255-263. doi:10.14573/altex.2009.4.255

Hartung, T. (2010a). Evidence based-toxicology – The toolbox of validation for the 21st century? ALTEX 27, 241-251. doi:10.14573/altex.2010.4.253

Hartung, T. (2010b). Food for thought ... on alternative methods for nanoparticle safety testing. ALTEX 27, 87-95. doi:10.14573/altex.2010.2.87

Hartung, T. (2010c). Food for thought ...on alternative methods for chemical safety testing. ALTEX 27, 3-14. doi:10.14573/altex.2010.1.3

Hartung, T. (2010d). Comparative analysis of the revised Directive 2010/63/EU for the protection of laboratory animals with its predecessor 86/609/EEC. ALTEX 27, 285-303. doi:10.14573/altex.2010.4.285

Hartung, T. and McBride, M. (2011). Food for thought… on mapping the human toxome. ALTEX 28, 83-93. doi:10.14573/altex.2011.2.083

Hartung, T., Blaauboer, B. J., Bosgra, S. et al. (2011). An expert consortium review of the EC-commissioned report “Alternative (non-animal) methods for cosmetics testing: Current status and future prospects – 2010”. ALTEX 28, 183-209. doi:10.14573/altex.2011.3.183

Hartung, T. and Zurlo, J. (2012). Alternative approaches for medical countermeasures to biological and chemical terrorism and warfare. ALTEX 29, 251-260. doi:10.14573/altex.2012.3.251

Hartung, T., van Vliet, E., Jaworska, J. et al. (2012). Systems toxicology. ALTEX 29, 119-128. doi:10.14573/altex.2012.2.119

Hartung, T. (2013). Look back in anger – What clinical studies tell us about preclinical work. ALTEX 30, 275-291. doi:10.14573/altex.2013.3.275

Hartung, T. and Corsini, E. (2013). Immunotoxicology: Challenges in the 21st century and in vitro opportunities. ALTEX 30, 411-426. doi:10.14573/altex.2013.4.411

Hartung, T., Luechtefeld, T., Maertens, A. et al. (2013a). Integrated testing strategies for safety assessments. ALTEX 30, 3-18. doi:10.14573/altex.2013.1.003

Hartung, T., Stephens, M. and Hoffmann, S. (2013b). Mechanistic validation. ALTEX 30, 119-130. doi:10.14573/altex.2013.2.119

Hartung, T. (2015). The human whole blood pyrogen test – Lessons learned in twenty years. ALTEX 32, 79-100. doi:10.14573/altex.1503241

Hartung, T. (2016a). Making big sense from big data in toxicology by read-across. ALTEX 33, 83-93. doi:10.14573/altex.1603091

Hartung, T. (2016b). E-Cigarettes and the need and opportunities for alternatives to animal testing. ALTEX 33, 211-224. doi:10.14573/altex.1606291

Hartung, T. (2016c). Can we wait for e-cigarette trials? Chemistry World. http://www.rsc.org/chemistryworld/2016/04/electronic-cigarettes-trials-vaping-safety-data

Hartung, T. (2016d). E-cigarettes – The ugly duckling of public health? Sci Am 315, 9.

Hartung, T. (2017a). Thresholds of toxicological concern – Setting a threshold for testing where there is little concern. ALTEX 34, 331-351. doi:10.14573/altex.1707011

Hartung, T. (2017b). Opinion versus evidence for the need to move away from animal testing. ALTEX 34, 193-200. doi:10.14573/altex.1703291

Hartung, T. (2017c). Utility of the adverse outcome pathway concept in drug development. Expert Opin Drug Metab Toxicol 13, 1-3. doi:10.1080/17425255.2017.1246535

Hartung, T. (2017d). Food for thought … the first ten years. ALTEX 34, 187-192. doi:10.14573/altex.1703311

Hartung, T., FitzGerald, R., Jennings, P.et al. (2017). Systems toxicology – Real world applications and opportunities. Chem Res Toxicol 30, 870-882. doi:10.1021/acs.chemrestox.7b00003

Hartung, T. (2018a). Rebooting the generally recognized as safe (GRAS) approach for food additive safety in the US. ALTEX 35, 3-25. doi:10.14573/altex.1712181

Hartung, T. (2018b). Making big sense from big data. Front Big Data 1, 5. doi:10.3389/fdata.2018.00005

Hartung, T. (2018c). Perspectives on in vitro to in vivo extrapolations. J Appl In Vitro Toxicol 4, 305-316. doi:10.1089/aivt.2016.0026

Hartung, T., de Vries, R., Hoffmann, S. et al. (2019). Toward good in vitro reporting standards. ALTEX 36, 3-17. doi:10.14573/altex.1812191

Hartung, T. (2021a). Pyrogen testing revisited on occasion of the 25th anniversary of the whole blood test. ALTEX 38, 3-19. doi:10.14573/altex.2101051

Hartung, T. (2021b). Evidence integration in the era of information flooding – The advent of the comprehensive review. Front Public Health 9, 763828. doi:10.3389/fpubh.2021.763828

Hartung, T. and Tsatsakis, A. M. (2021). The state of the scientific revolution in toxicology. ALTEX 38, 379-386. doi:10.14573/altex.2106101

Hasiwa, N., Bailey, J., Clausing, P. et al. (2011). Critical evaluation of the use of dogs in biomedical research and testing in Europe. ALTEX 28, 326-340. doi:10.14573/altex.2011.4.326

Hasiwa, N., Daneshian, M., Bruegger, P. et al. (2013). Evidence for the detection of non-endotoxin pyrogens by the whole blood monocyte activation test. ALTEX 30, 169-208. doi:10.14573/altex.2013.2.169

Heinonen, T. (2015). Better science with human cell-based organ and tissue models. Altern Lab Anim 43, 29-38. doi:10.1177/026119291504300107

Helman, G., Shah, I., Williams, A. J. et al. (2019). Generalized read-across (GenRA): A workflow implemented into the EPA CompTox chemicals dashboard. ALTEX 36, 462-465. doi:10.14573/altex.1811292

Hermann, K., Pistollato, F. and Stephens, M. (2019). Beyond the 3Rs: Expanding the use of human-relevant replacement methods in biomedical research. ALTEX 36, 343-352. doi:10.14573/altex.1907031

Herzler, M., Marx-Stoelting, P., Pirow, R. et al. (2021). The “EU chemicals strategy for sustainability” questions regulatory toxicology as we know it: Is it all rooted in sound scientific evidence? Arch Toxicol 95, 2589-2601. doi:10.1007/s00204-021-03091-3

Hoffmann, S. and Hartung, T. (2006a). Designing validation studies more efficiently according to the modular approach: Retrospective analysis of the EPISKIN test for skin corrosion. Altern Lab Anim 34, 177-191. doi:10.1177/026119290603400209

Hoffmann, S. and Hartung, T. (2006b). Towards an evidence-based toxicology. Hum Exp Toxicol 25, 497-513. doi:10.1191/0960327106het648oa

Hoffmann, S., Edler, L., Gardner, I. et al. (2008). Points of reference in validation – The report and recommendations of ECVAM workshop. Altern Lab Anim 36, 343-352. doi:10.1177/026119290803600311

Hoffmann, S., de Vries, R. B. M., Stephens, M. L. et al. (2017). A primer on systematic reviews in toxicology. Arch Toxicol 91, 2551-2575. doi:10.1007/s00204-017-1980-3

Hoffmann, S., Margliani, B., Akgün-Ölmez, S. G. et al. (2021). A systematic review to compare chemical hazard predictions of the zebrafish embryo test with mammalian prenatal developmental toxicity. Toxicol Sci 183, 14-35. doi:10.1093/toxsci/kfab072

Hoffmann, S., Whaley, P. and Tsaioun, K. (2022a). How evidence-based methodologies can help identify and reduce uncertainty in chemical risk assessment. ALTEX 39, 175-182. doi:10.14573/altex.2201131

Hoffmann, S., Aiassa, E., Angrish, M. et al. (2022b). Application of evidence-based methods to construct mechanism-driven chemical assessment frameworks. ALTEX 39, 499-518. doi:10.14573/altex.2202141

Jacobs, M. N., Versteegen, R. J., Treasure, C. et al. (2019). Addressing potential ethical issues regarding the supply of human-derived products or reagents in in vitro OECD test guidelines. ALTEX 36, 163-176. doi:10.14573/altex.1901281

Jahn, S. W., Plass, M. and Moinfar, F. (2020). Digital pathology: Advantages, limitations and emerging perspectives. J Clin Med 18, 3697. doi:10.3390/jcm9113697

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Juberg, D. R., Borghoff, S. J., Becker, R. A. et al. (2014). Lessons learned, challenges, and opportunities: The U.S. endocrine disruptor screening program. ALTEX 31, 63-78. doi:10.14573/altex.1309171

Kang, I., Smirnova, L., Kuhn, J. H. et al. (2021). COVID-19 – Prime time for microphysiological systems, as illustrated for the brain. ALTEX 38, 535-549. doi:10.14573/altex.2110131

Kerecman Myers, D., Goldberg, A. M., Poth, A. et al. (2017). From in vivo to in vitro: The medical device testing paradigm shift. ALTEX 34, 479-500. doi:10.14573/altex.1608081

Kim, J. A., Han, E., Eun, C. J. et al. (2012). Real-time concurrent monitoring of apoptosis, cytosolic calcium, and mitochondria permeability transition for hypermulticolor high-content screening of drug-induced mitochondrial dysfunction-mediated hepatotoxicity. Toxicol Lett 214, 175-181. doi:10.1016/j.toxlet.2012.08.027

Kirkland, D., Pfuhler, S., Tweats, D. et al. (2007). How to reduce false positive results when undertaking in vitro genotoxicity testing and thus avoid unnecessary follow-up animal tests: Report of an ECVAM workshop. Mutat Res 628, 31-55. doi:10.1016/j.mrgentox.2006.11.008

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