Welcome
Clément Gauthier and Herman Koëter 

Editorial
Sonja von Aulock

Program overview

Plenary talks

Theme I
Safety and Efficacy Testing of Chemicals, Pharmaceuticals and Biologicals
I-1          Potency and safety testing of human vaccines
I-2          Addressing systems toxicology
I-3          Biological and biotechnology-based therapeutics
I-4          Regulatory testing paradigms and validation of alternative test methods for detecting estrogen active substances; impact on the Three Rs
I-5          Nanotoxicology and the Three Rs
I-6          Advances in alternative methods for ecotoxicology
I-7          Potency and safety testing of veterinary vaccines
I-8          Safety testing for chemically-induced eye injuries: Recent Three Rs advances
I-9          Advances in Three Rs alternatives for reproductive and developmental toxicity
I-10        Safety testing for carcinogenicity and genetic toxicity: Recent Three Rs advances
I-11        Safety testing for skin sensitization hazards: Recent Three Rs advances
I-12        Epigenetics and its increasing relevance in toxicology and risk assessment
I-13        Toxicity testing in the 21st century
I-15        Shellfish toxin testing: How are the Three Rs being progressed in this field?
I-16        Alternatives for potency testing of rabies vaccines
I-18        Report on the ICCVAM International Workshop on Vaccines
I-19        Toxicity testing strategies – progress in skin sensitization testing: A COLIPA supported session

Theme II
Policy/Law on Animal Use, Public Engagement and Ethics Review
II-1         Public accountability
II-2         Ethics review
II-3         Public law – the Three Rs in regulation addressing animal use
II-4         Implementing the Three Rs – alternatives to legislation
II-5         Validation of Three Rs alternative methods
II-6         Setting limits and resolving conflicts between the Rs

Theme III
Incorporation of the Three Rs in Education and Training
III-1       Innovative teaching in the life sciences
III-2       Innovative training in human and veterinary medicine
III-3       Development of non-animal teaching/training models
III-4       Replacement alternatives and teaching objectives – determining if and when student learning objectives require the use of animals
III-5       Introducing multi-media to the curriculum
III-6       Training animal-based scientists 

Theme IV
Animal Welfare for Refinement and High Quality Science
IV-1       Indicators of animal welfare to implement refinement
IV-2       Farm animal research and the Three Rs
IV-3       Wildlife science and the Three Rs
IV-4       Multi-imaging modalities, telemetry and the Three Rs
IV-5       Can pain research benefit research animals?
IV-6       Broadening the application of Refinement

Theme V
Replacement and Reduction in Basic Research
V-1         Novel methodologies and their potential in vitro application for drug development and safety assessment
V-2         Systematic reviews of animal experiments
V-3         Cell culture and tissue engineering
V-4         Replacement and Reduction in the use of genetically-engineered animals
V-5         Developments in stem cell research as the basis for sustainable availability
of differentiated human cells and tissues
V-6         Animal reduction through the better use of mechanistically-based translational animal disease models
V-9         Improving reporting of animal-based research

Author Index
Imprint
Acknowledgment of Sponsors
Invitation to WC9