EPA updates List of Alternative Test Methods and Strategies (or New Approach Methodologies [NAMs])

Posted on 2019-12-10

The U.S. has EPA released an updated version of its List of Alternative Test Methods and Strategies (or New Approach Methodologies [NAMs]). The document can be viewed here:

https://www.epa.gov/sites/production/files/2019-12/documents/alternative_testing_nams_list_first_update_final.pdf

The list contains links to test guidelines, method protocols, computational tools and databases, and guidances and policies from EPA  that "do not use vertebrate animals to develop new data/information," and additional guidance or other documents that are considered "tools and approaches which may enhance the use of NAMs for regulatory use under TSCA."

New additions to the list include:

  • The ToxCast Estrogen Receptor Agonist Pathway Model
  • In vitro BALB/c 3T3 Cell Transformation Assay
  • Determination of in vitro intrinsic clearance using rainbow trout hepatocytes (OECD TG NO. 319A)
  • Determination of in vitro intrinsic clearance using rainbow trout liver S9 sub-cellular fraction (RT-S9) (OECD TG NO. 319B)
  • Several guidance documents related to waiving or bridging or alternative approaches for acute systemic toxicity, eye irritation, skin sensitization, and endocrine disruption
  • FIFRA SAP reports on endocrine disruption, respiratory toxicity, and the EPA CompTox Chemicals Dashboard

 

 

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