Latest Articles

Latest Articles

Latest Articles are manuscripts that have recently been accepted for publication in ALTEX but have not yet undergone editing, layout, and proofreading. They are replaced by a final version with the same doi upon print publication in an issue of ALTEX.

Workshop report on the evaluation of the updated and expanded carcinogen database to support derivation of threshold of toxicological concern values for DNA reactive carcinogens

Sylvia E. Escher, Susan P. Felter, Heli Hollnagel, Alan R. Boobis, Chihae Yang, James Rathman, Mark T. D. Cronin, Monika Batke
Published: Nov 11, 2022
accepted manuscript

Report on 2021 International Workshop for Non-animal Approaches in the Food Sector (Japan): Current status and avenues for further research

Satoshi Ohta, Shigeki Kimura, Daisuke Maejima, Kazutoshi Saito, Yasuhiro Tanaka, Satoshi Kojima, Tomohiro Kawaguchi, Takuya Kikuchi, Takuya Seki, Hsuan Chung, Risa Funaki, Tetsuya Kuhara, Hisako Hori, Yuichi Ito
Published: Nov 10, 2022
accepted manuscript

Novel prediction models for genotoxicity based on biomarker genes in human HepaRGâ„¢ cells

Anouck Thienpont, Stefaan Verhulst, Leo A. van Grunsven, Vera Rogiers, Tamara Vanhaecke, Birgit Mertens
Published: Nov 4, 2022
accepted manuscript sup1 sup2

Amplifying the impact of kidney microphysiological systems: predicting renal drug clearance using mechanistic modelling based on reconstructed drug secretion

Pedro Caetano-Pinto, Pär Nordell, Tom Nieskens, Katie Haughan, Katherine S. Fenner, Simone H. Stahl
Published: Nov 3, 2022
accepted manuscript sup

The GARDâ„¢skin assay: Investigation of the applicability domain for metals

Andy Forreryd, Robin Gradin, Olivia Larne, Nissanka Rajapakse, Eliot Deag, Henrik Johansson
Published: Nov 3, 2022
accepted manuscript sup

Proceedings of a workshop to address animal methods bias in scientific publishing

Catharine E. Krebs, Celean Camp, Helder Constantino, Lilas Courtot, Owen Kavanagh, Sofia Batista Leite, Judith Madden, Alicia Paini, Brinda Poojary, Ignacio J. Tripodi, Emily R. Trunnell
Published: Oct 31, 2022
accepted manuscript sup

Comparison of piecewise structural equation modeling and Bayesian network for de novo construction of a quantitative adverse outcome pathway network

Yang Cao, S. Jannicke Moe, Riccardo de Bin, Knut Erik Tollefsen, You Song
Published: Oct 12, 2022
accepted manuscript

Evaluation of 147 perfluoroalkyl substances for immunotoxic and other (patho)physiological activities through phenotypic screening of human primary cells

Keith A. Houck, Katie Paul Friedman, Madison Feshuk, Grace Patlewicz, Marci Smeltz, M. Scott Clifton, Barbara A. Wetmore, Sharlene Velichko, Antal Berenyi, Ellen L. Berg
Published: Sep 15, 2022
accepted manuscript sup1 sup2 sup3 sup4 sup5 sup6

Application of immunocompetent microphysiological systems in drug development: Current perspective and recommendations

Xiaoting Wang, Anna K. Kopec, Mark Collinge, Rhiannon David, Christian Grant, Rhiannon N. Hardwick, Aaron Navratil, Nirav Patel, Wendy Rowan, Nikki Marshall
Published: Aug 29, 2022
accepted manuscript

Impact of in vitro experimental variation in kinetic parameters on physiologically based kinetic (PBK) model simulations

Ans Punt, Peter Bos, Betty Hakkert, Jochem Louisse
Published: Jul 25, 2022
accepted manuscript sup1 sup2

Technical framework for enabling high-quality measurements in new approach methodologies (NAMs)

Elijah J. Petersen, John T. Elliott, John Gordon, Nicole C. Kleinstreuer, Emily Reinke, Mattias Roesslein, Blaza Toman
Published: Jul 15, 2022
accepted manuscript

Comparison of pyrogen assays by testing products exhibiting low endotoxin recovery

Tammy L. Thurman, Carol J. Lahti, Jeanne M. Mateffy, Ren-Yo Forng, Friedrich von Wintzingerode, Lindsey M. Silva, Sven M. Deutschmann, Ned M. Mozier
Published: Jun 24, 2022
accepted manuscript sup

Identifying candidate reference chemicals for in vitro testing of the retinoid pathway for predictive developmental toxicity

Nancy C. Baker, Jocylin D. Pierro, Laura W. Taylor, Thomas B. Knudsen
Published: Jun 23, 2022
accepted manuscript sup

How to formulate hypotheses and IATAs to support grouping and read-across of nanoforms

Fiona A. Murphy, Helinor J. Johnston, Susan Dekkers, Eric A. J. Bleeker, Agnes G. Oomen, Teresa F. Fernandes, Kirsten Rasmussen, Paula Jantunen, Hubert Rauscher, Neil Hunt, Luisana di Cristo, Hedwig M. Braakhuis, Andrea Haase, Danail Hristozov, Wendel Wohlleben, Stefania Sabella, Vicki Stone
Published: Jun 22, 2022
accepted manuscript sup

A rodent thyroid-liver chip to capture thyroid toxicity on organ functional level

Diana Karwelat, Julia Kühnlenz, Thomas Steger-Hartmann, Remi Bars, Helen Tinwell, Uwe Marx, Sophie Bauer, Oliver Born, Marian Raschke
Published: Jun 21, 2022
accepted manuscript sup

Comparison of human recombinant protein coatings and fibroblast-ECM to Matrigel for induced pluripotent stem cell culture and renal podocyte differentiation

Cormac Murphy, Elisabeth Naderlinger, Amber Mater, Roelof J. C. Kluin, Anja Wilmes
Published: Jun 20, 2022
accepted manuscript sup1 sup2

Beyond pharmaceuticals: Fit-for-purpose new approach methodologies for environmental cardiotoxicity testing

Mark C. Daley, Ulrike Mende, Bum-Rak Choi, Patrick D. McMullen, Kareen L. K. Coulombe
Published: Jun 1, 2022
accepted manuscript

Development of a network of carcinogenicity adverse outcome pathways and its employment as an evidence framework for safety assessment

Alex N. Cayley, Robert S. Foster, Emma Hill, Steven Kane, Grace Kocks, Alun Myden, Daniel Newman, Susanne A. Stalford, Jonathan D. Vessey, Reza Zarei, Antonio Anax F. de Oliveira
Published: May 13, 2022
accepted manuscript

A microfluidic thyroid-liver platform to assess chemical safety in humans

Julia Kühnlenz, Diana Karwelat, Thomas Steger-Hartmann, Marian Raschke, Sophie Bauer, Özlem Vural, Uwe Marx, Helen Tinwell, Remi Bars
Published: May 9, 2022
accepted manuscript sup

Exploration of the GARDâ„¢skin applicability domain: Indirectly acting haptens, hydrophobic substances and UVCBs

Andy Forreryd, Robin Gradin, Charles Humfrey, Len Sweet, Henrik Johansson
Published: Apr 21, 2022
accepted manuscript sup

A novel coculture system for assessing respiratory sensitizing potential by IL-4 in T cells

Izuru Mizoguchi, Yasuhiro Katahira, Shinya Inoue, Eri Sakamoto, Aruma Watanabe, Yuma Furusaka, Atsushi Irie, Satoru Senju, Yasuharu Nishimura, Shusaku Mizukami, Kenji Hirayama, Sou Nakamura, Koji Eto, Hideaki Hasegawa, Takayuki Yoshimoto
Published: Feb 24, 2022
accepted manuscript sup