Latest Articles

Latest Articles

Latest Articles are manuscripts that have recently been accepted for publication in ALTEX but have not yet undergone editing, layout, and proofreading. They are replaced by a final version with the same doi upon print publication in an issue of ALTEX.

Incorporating new approach methodologies into regulatory nonclinical pharmaceutical safety assessment

Jan Turner, Pandora Pound, Carla Owen, Isobel Hutchinson, Marina Hop, David Y. S. Chau, Lady V. Barrios Silva, Mike Coleman, Audrey Dubourg, Lorna W. Harries, Victoria Hutter, J- Gerry Kenna, Volker M. Lauschke, Winfried Neuhaus, Clive Roper, Paul B. Watkins, Jonathan Welch, Laura R: Alvarez, Katy Taylor
Published: Jan 18, 2023

Cardiotoxicity of chemicals: Current regulatory guidelines, knowledge gaps, and needs

Alexandra Schaffert, Sivakumar Murugadoss, Birgit Mertens, Martin Paparella
Published: Jan 13, 2023

Applications of microphysiological systems to disease models in the biopharmaceutical industry: Opportunities and challenges

Onyi Irrechukwu, Ronnie Yeager, Rhiannon David, Jason Ekert, Anitha Saravanakumar, Colin K. Choi
Published: Jan 12, 2023

Microphysiological endothelial models to characterize subcutaneous drug absorption

Giovanni S. Offeddu, Jean Carlos Serrano, Zhengpeng Wan, Mark A. Bryniarski, Sara C. Humphreys, Sophia W. Chen, Hamsini Dhoolypala, Kip Conner, Roger D. Kamm
Published: Dec 15, 2022

Workshop report on the evaluation of the updated and expanded carcinogen database to support derivation of threshold of toxicological concern values for DNA reactive carcinogens

Sylvia E. Escher, Susan P. Felter, Heli Hollnagel, Alan R. Boobis, Chihae Yang, James Rathman, Mark T. D. Cronin, Monika Batke
Published: Nov 11, 2022

Report on 2021 International Workshop for Non-animal Approaches in the Food Sector (Japan): Current status and avenues for further research

Satoshi Ohta, Shigeki Kimura, Daisuke Maejima, Kazutoshi Saito, Yasuhiro Tanaka, Satoshi Kojima, Tomohiro Kawaguchi, Takuya Kikuchi, Takuya Seki, Hsuan Chung, Risa Funaki, Tetsuya Kuhara, Hisako Hori, Yuichi Ito
Published: Nov 10, 2022

Novel prediction models for genotoxicity based on biomarker genes in human HepaRG™ cells

Anouck Thienpont, Stefaan Verhulst, Leo A. van Grunsven, Vera Rogiers, Tamara Vanhaecke, Birgit Mertens
Published: Nov 4, 2022

The GARD™skin assay: Investigation of the applicability domain for metals

Andy Forreryd, Robin Gradin, Olivia Larne, Nissanka Rajapakse, Eliot Deag, Henrik Johansson
Published: Nov 3, 2022

Proceedings of a workshop to address animal methods bias in scientific publishing

Catharine E. Krebs, Celean Camp, Helder Constantino, Lilas Courtot, Owen Kavanagh, Sofia Batista Leite, Judith Madden, Alicia Paini, Brinda Poojary, Ignacio J. Tripodi, Emily R. Trunnell
Published: Oct 31, 2022

Evaluation of 147 perfluoroalkyl substances for immunotoxic and other (patho)physiological activities through phenotypic screening of human primary cells

Keith A. Houck, Katie Paul Friedman, Madison Feshuk, Grace Patlewicz, Marci Smeltz, M. Scott Clifton, Barbara A. Wetmore, Sharlene Velichko, Antal Berenyi, Ellen L. Berg
Published: Sep 15, 2022

Application of immunocompetent microphysiological systems in drug development: Current perspective and recommendations

Xiaoting Wang, Anna K. Kopec, Mark Collinge, Rhiannon David, Christian Grant, Rhiannon N. Hardwick, Aaron Navratil, Nirav Patel, Wendy Rowan, Nikki Marshall
Published: Aug 29, 2022

A novel coculture system for assessing respiratory sensitizing potential by IL-4 in T cells

Izuru Mizoguchi, Yasuhiro Katahira, Shinya Inoue, Eri Sakamoto, Aruma Watanabe, Yuma Furusaka, Atsushi Irie, Satoru Senju, Yasuharu Nishimura, Shusaku Mizukami, Kenji Hirayama, Sou Nakamura, Koji Eto, Hideaki Hasegawa, Takayuki Yoshimoto
Published: Feb 24, 2022