Latest Articles

Latest Articles

Latest Articles are manuscripts that have recently been accepted for publication in ALTEX but have not yet undergone editing, layout, and proofreading. They are replaced by a final version with the same doi upon print publication in an issue of ALTEX.

Protectiveness of NAM-based hazard assessment – which testing scope is required?

Walter Zobl, Annette Bitsch, Jonathan Blum, Jan J. W. A. Boei, Liliana Capinha, Giada Carta, Jose Castell, Enrico Davoli, Christina Drake, Ciaran P. Fisher, Muriel M. Heldring, Barira Islam, Paul Jennings, Marcel Leist, Damiano Pellegrino-Coppola, Johannes P. Schimming, Kirsten E. Snijders, Laia Tolosa, Bob van de Water, Barbara M. A. van Vugt-Lussenburg, Paul Walker, Matthias M. Wehr, Lukas S. Wijaya, Sylvia E. Escher
Published: Dec 4, 2023
accepted manuscript sup1 sup2 sup3

Toward implementing virtual control groups in nonclinical safety studies

Workshop report and roadmap to implementation

Emily Golden, David Allen, Alexander Amberg, Lennart T. Anger, Elizabeth Baker, Szczepan W. Baran, Frank Bringezu, Matthew Clark, Guillemette Duchateau-Nguyen, Sylvia E. Escher, Varun Giri, Armelle Grevot, Thomas Hartung, Dean (Dingzhou) Li, Wolfgang Muster, Kevin Snyder, Ronald Wange, Thomas Steger-Hartmann
Published: Dec 1, 2023
accepted manuscript

Pollutant exposure and myocardial injury: Protocol and progress report for a toxicological systematic mapping review

Tom Roos, Cathalijn Leenaars, Alexandra Schaffert, Martin Paparella, Sivakumar Murugadoss, Birgit Mertens, Nunzia Linzalone, Gabriele Donzelli, Merel Ritskes-Hoitinga, Ronette Gehring
Published: Nov 20, 2023
accepted manuscript sup

Beyond chemicals: Opportunities and challenges of integrating non-chemical stressors in adverse outcome pathways

Laure-Alix Clerbaux, Julija Filipovska, Penny Nymark, Vinita Chauhan, Katherina Sewald, Madgalini Sachana, Anna Beronius, Maria-Joao Amorim, Clemens Wittwehr
Published: Nov 17, 2023
accepted manuscript

In vitro model of neurotrauma using the chick embryo to test regenerative bioimplantation

Aina Mogas Barcons, Divya M. Chari, Christopher Adams
Published: Nov 2, 2023
accepted manuscript

Assessing proarrhythmic potential of environmental chemicals using a high throughput in vitro-in silico model with human induced pluripotent stem cell-derived cardiomyocytes

Hsing-Chieh Lin, Ivan Rusyn, Weihsueh A. Chiu
Published: Oct 20, 2023
accepted manuscript sup1 sup2

Challenges integrating skin sensitization data for assessment of difficult to test substances

Allison Greminger, Joseph Frasca, Katy Goyak, Colin North
Published: Oct 12, 2023
accepted manuscript sup

The importance of variations in in vitro dosimetry to support risk assessment of inhaled toxicants

Yvonne C. M. Staal, Liesbeth Geraets, Barbara Rothen-Rutishauser, Martin J. D. Clift, Hedwig Braakhuis, Anne S. Kienhuis, Peter M. J. Bos
Published: Oct 12, 2023
accepted manuscript sup1 sup2 sup3

Developing prototypes of a modernized approach to assess crop protection chemical safety

Richard Currie, John Abbott, David A. Dreier, Haitian Lu, Tharacad Ramanarayanan, Natalia Ryan, Odette A. Watkins, Douglas C. Wolf
Published: Aug 31, 2023
accepted manuscript

Linking nanomaterial-induced mitochondrial dysfunction to existing adverse outcome pathways for chemicals

Sivakumar Murugadoss, Ivana Vinković Vrček, Alexandra Schaffert, Martin Paparella, Barbara Pem, Anita Sosnowska, Maciej Stępnik, Marvin Martens, Egon L. Willighagen, Tomasz Puzyn, Mihaela Roxana Cimpan, Frauke Lemaire, Birgit Mertens, Maria Dusinska, Valérie Fessard, Peter H. Hoet
Published: Aug 21, 2023
accepted manuscript sup1 sup2

Beyond Animal Testing Index: Benchmarking tool for a world beyond animal testing

Cyrille Krul, Annick De Moor, Koen Stegmeijer, Reinout Stoop, Judith Van Luijk, Jan-Bas Prins
Published: Aug 8, 2023
accepted manuscript sup1 sup2 sup3 sup4 sup5

Development of a monoclonal antibody sandwich ELISA for the determination of antigen content and quality in diphtheria vaccines

Laura Hassall, Daniel A. Yara, Rebecca Riches-Duit, Peter Rigsby, Alexandre Dobly, Maxime Vermeulen, Antoine Francotte, Paul Stickings
Published: Aug 7, 2023
accepted manuscript

Why adverse outcome pathways need to be FAIR

Clemens Wittwehr, Laure-Alix Clerbaux, Stephen Edwards, Michelle Angrish, Holly Mortensen, Annamaria Carusi, Maciej Gromelski, Eftychia Lekka, Vassilis Virvilis, Marvin Martens, Luiz Olavo Bonino da Silva Santos, Penny Nymark
Published: Aug 1, 2023
accepted manuscript

Intestinal in vitro transport assay combined with physiologically based kinetic modeling as a tool to predict bile acid levels in vivo

Véronique M. P. de Bruijn, Willem te Kronnie, Ivonne M. C. M. Rietjens, Hans Bouwmeester
Published: Jul 27, 2023
accepted manuscript sup1 sup2