Latest Articles

Latest Articles

Latest Articles are manuscripts that have recently been accepted for publication in ALTEX but have not yet undergone editing, layout, and proofreading. They are replaced by a final version with the same doi upon print publication in an issue of ALTEX.

Impact of in vitro experimental variation in kinetic parameters on physiologically based kinetic (PBK) model simulations

Ans Punt, Peter Bos, Betty Hakkert, Jochem Louisse
Published: Jul 25, 2022
accepted manuscript sup1 sup2

Technical framework for enabling high-quality measurements in new approach methodologies (NAMs)

Elijah J. Petersen, John T. Elliott, John Gordon, Nicole C. Kleinstreuer, Emily Reinke, Mattias Roesslein, Blaza Toman
Published: Jul 15, 2022
accepted manuscript

Comparison of pyrogen assays by testing products exhibiting low endotoxin recovery

Tammy L. Thurman, Carol J. Lahti, Jeanne M. Mateffy, Ren-Yo Forng, Friedrich von Wintzingerode, Lindsey M. Silva, Sven M. Deutschmann, Ned M. Mozier
Published: Jun 24, 2022
accepted manuscript sup

Identifying candidate reference chemicals for in vitro testing of the retinoid pathway for predictive developmental toxicity

Nancy C. Baker, Jocylin D. Pierro, Laura W. Taylor, Thomas B. Knudsen
Published: Jun 23, 2022
accepted manuscript sup

How to formulate hypotheses and IATA to support grouping and read-across of nanoforms

Fiona A. Murphy, Helinor J. Johnston, Susan Dekkers, Eric A. J. Bleeker, Agnes G. Oomen, Teresa F. Fernandes, Kirsten Rasmussen, Paula Jantunen, Hubert Rauscher, Neil Hunt, Luisana di Cristo, Hedwig M. Braakhuis, Andrea Haase, Danail Hristozov, Wendel Wohlleben, Stefania Sabella, Vicki Stone
Published: Jun 22, 2022
accepted manuscript sup

A rodent thyroid-liver chip to capture thyroid toxicity on organ functional level

Diana Karwelat, Julia Kühnlenz, Thomas Steger-Hartmann, Remi Bars, Helen Tinwell, Uwe Marx, Sophie Bauer, Oliver Born, Marian Raschke
Published: Jun 21, 2022
accepted manuscript sup

Comparison of human recombinant protein coatings and fibroblast-ECM to Matrigel for induced pluripotent stem cell culture and renal podocyte differentiation

Cormac Murphy, Elisabeth Naderlinger, Amber Mater, Roelof J. C. Kluin, Anja Wilmes
Published: Jun 20, 2022
accepted manuscript sup1 sup2

Beyond pharmaceuticals: Fit-for-purpose new approach methodologies for environmental cardiotoxicity testing

Mark C. Daley, Ulrike Mende, Bum-Rak Choi, Patrick D. McMullen, Kareen L. K. Coulombe
Published: Jun 1, 2022
accepted manuscript

Development of a network of carcinogenicity adverse outcome pathways and its employment as an evidence framework for safety assessment

Alex N. Cayley, Robert S. Foster, Emma Hill, Steven Kane, Grace Kocks, Alun Myden, Daniel Newman, Susanne A. Stalford, Jonathan D. Vessey, Reza Zarei, Antonio Anax F. de Oliveira
Published: May 13, 2022
accepted manuscript

A microfluidic thyroid-liver platform to assess chemical safety in humans

Julia Kühnlenz, Diana Karwelat, Thomas Steger-Hartmann, Marian Raschke, Sophie Bauer, Özlem Vural, Uwe Marx, Helen Tinwell, Remi Bars
Published: May 9, 2022
accepted manuscript sup

Exploration of the GARDskin applicability domain: Indirectly acting haptens, hydrophobic substances and UVCBs

Andy Forreryd, Robin Gradin, Charles Humfrey, Len Sweet, Henrik Johansson
Published: Apr 21, 2022
accepted manuscript

Dog as the experimental model: Laboratory uses of dogs in the United States

Sherry L. Ward, Pamela Osenkowski
Published: Apr 21, 2022
accepted manuscript sup

Assessment of a 3D neural spheroid model to detect pharmaceutical-induced neurotoxicity

Qin Wang, Jennifer D. Cohen, Tomoya Yukawa, Heather Estrella, Chris Leonard, Jairo Nunes, Colin Choi, Lauren Lewis, Kevin S. Baker, Kazuhiro Kuga, Yvonne P. Dragan, Matthew P. Wagoner, Nibha Mishra
Published: Apr 19, 2022
accepted manuscript sup1 sup2 sup3 (video)

Validation of the monocyte activation test with three therapeutic monoclonal antibodies

Ruth Daniels, Wim Van der Elst, Nele Dieltjens, Tinne Appels, Chi K. So, Thomas Nys, Liesbeth Voeten, Philip Breugelmans, Marijke W. A. Molenaar-de Backer, Eelo Gitz, Stephen Poole, Mehul Patel
Published: Apr 14, 2022
accepted manuscript sup

Integrated skin sensitization assessment based on OECD methods (II): Hazard and potency by combining kinetic peptide reactivity and the “2 out of 3” Defined Approach

Andreas Natsch, G. Frank Gerberick
Published: Apr 11, 2022
accepted manuscript ESM1 ESM2 ESM3 ESM4

Integrated skin sensitization assessment based on OECD methods (I): Deriving a point of departure for risk assessment

Andreas Natsch, G. Frank Gerberick
Published: Apr 11, 2022
accepted manuscript ESM1 ESM2 ESM3 ESM4

The future of Parkinson’s disease research: A new paradigm of human-specific investigation is necessary… and possible

Manuela Cassotta, Hugo Geerts, Lise Harbom, Tiago F. Outeiro, Iosif Pediaditakis, Orly Reiner, Stefan Schildknecht, Jens C. Schwamborn, Jarrod Bailey, Kathrin Herrmann, Helena T. Hogberg
Published: Apr 8, 2022
accepted manuscript

The use of categorical regression in evidence integration

Patrick J. Farrell, Peter Aggett, Brittany Milton, Siva Ramoju, Don Mattison, Nicholas Birkett, Daniel Krewski
Published: Mar 30, 2022
accepted manuscript sup

Evaluation of an in vitro three-dimensional HepaRG spheroid model for genotoxicity testing using the high-throughput CometChip platform

Ji-Eun Seo, Xiaobo He, Levan Muskhelishvili, Pritpal Malhi, Nan Mei, Mugimane Manjanatha, Matthew Bryant, Tong Zhou, Timothy Robison, Xiaoqing Guo
Published: Mar 18, 2022
accepted manuscript sup

A novel coculture system for assessing respiratory sensitizing potential by IL-4 in T cells

Izuru Mizoguchi, Yasuhiro Katahira, Shinya Inoue, Eri Sakamoto, Aruma Watanabe, Yuma Furusaka, Atsushi Irie, Satoru Senju, Yasuharu Nishimura, Shusaku Mizukami, Kenji Hirayama, Sou Nakamura, Koji Eto, Hideaki Hasegawa, Takayuki Yoshimoto
Published: Feb 24, 2022
accepted manuscript sup