On March 12, NICEATM released the version 3.3 update of the Integrated Chemical Environment (ICE). ICE provides data and tools to help develop, assess, and interpret chemical safety tests. This release adds two new tools, new features including expanded activity visualization, and new datasets to existing ICE resources.

New tools:

  • Curve Surfer: allows users to view and interact with concentration-response curves from curated high-throughput screening data.
  • Physiologically Based Pharmacokinetics (PBPK) tool: this tool, based on the the U.S. Environmental Protection Agency (EPA) httk package (https://cran.r-project.org/web/packages/httk/index.html), allows users to generate predictions of tissue-specific chemical concentration profiles following a dosing event.

Updates to existing tools:

  • Search tool: users can get detailed visualization of query results.
  • In Vitro to In Vivo Extrapolation (IVIVE) tool: users can now upload their own in vivo data to overlay on the results.
  • Chemical Characterization: new visualizations include bioactivity PCA plots and Consumer Use Explorer, which allows users to view chemical use categories from the EPA Consumer Products Database (CPDat).

New data:

  • Cancer data from multiple sources, including detailed data from NTP two-year cancer bioassays and in vivo and in vitro genotoxicity studies.
  • Developmental and reproductive toxicity (DART) in vivo bioassays from the EPA‚Äôs Toxicity Reference Database (ToxRefDB).
  • Updated in vivo human predictive patch test data set for skin sensitization characterization compiled by NICEATM and the German Federal Institute for Risk Assessment (BfR).

ICE is available at https://ice.ntp.niehs.nih.gov/.