The NIH Common Fund’s Complement Animal Research In Experimentation (Complement-ARIE) program seeks to speed the development, standardization, validation, and use of human-based new approach methodologies (NAMs). The Complement-ARIE program will build upon ongoing efforts related to NAMs, while identifying opportunities for innovation and coordination.

Complement-ARIE will significantly advance understanding of human health and disease by providing a range of ready and standardized biomedical research models. Developing these models will require expertise in disease research, personalized medicine, and in screening therapeutics for safety and effectiveness.

Complement-ARIE will bring these expertise together through a consortium of researchers participating in the following efforts:

  • Technology development projects/centers that will develop NAMs to fill in areas of greatest need. Projects will emphasize biological complexity, high throughput techniques, combining approaches, and data sharing.
  • A data & NAM resource coordinating center that will create integrated data structures and a searchable NAMs repository. 
  • A validation network that will accelerate deployment and regulatory approval of NAMs for biomedical research.
  • Community engagement and training that will promote the development of an inclusive, diverse, biomedical research workforce with the skills to build and use new NAMs. 
  • Strategic engagement with key partners that will advance emerging opportunities in development and use of NAMs in basic, translational, and clinical research.

To learn more about Complement-ARIE strategic planning activities, visit: Complement-ARIE strategic planning. 

To learn more about related work being done at NIH, visit: NIH NCATS Tissue Chip for Drug Screening Program